心臟生物標誌物在獸醫臨床中的應用解析

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心臟生物標誌物(如心肌鈣蛋白I和N末端B型利鈉肽原)在犬貓心臟疾病的診斷中展現高度潛力。這些血液檢測可協助區分心臟與非心臟因素引起的呼吸道症狀,及早期偵測潛在心肌病變。此外,生物標誌物還能預測心臟疾病患者的罹病及死亡風險,成為獸醫臨床診斷的重要輔助工具。

Using cardiac biomarkers in veterinary practice

在獸醫臨床中使用心臟生物標誌物

Oyama MA. Using cardiac biomarkers in veterinary practice. Vet Clin North Am Small Anim Pract. 2013;43(6):1261-vi. doi:10.1016/j.cvsm.2013.07.010

https://pubmed.ncbi.nlm.nih.gov/24144089/

Abstract

Blood-based assays for various cardiac biomarkers can assist in the diagnosis of heart disease in dogs and cats. The two most common markers are cardiac troponin-I and N-terminal pro-B-type natriuretic peptide. Biomarker assays can assist in differentiating cardiac from noncardiac causes of respiratory signs and detection of preclinical cardiomyopathy. Increasingly, studies indicate that cardiac biomarker testing can help assess the risk of morbidity and mortality in animals with heart disease. Usage of cardiac biomarker testing in clinical practice relies on proper patient selection, correct interpretation of test results, and incorporation of biomarker testing into existing diagnostic methods.

Keywords: BNP; Cardiac biomarkers; Heart disease; Natriuretic peptide; Troponin.

摘要

基於血液的各種心臟生物標誌物檢測有助於診斷犬貓的心臟疾病。最常見的兩種標誌物為心肌鈣蛋白I(Cardiac Troponin-I, cTnI)和N端B型利鈉肽原(N-terminal pro-B-type Natriuretic Peptide, NT-proBNP)。這些生物標誌物檢測有助於區分呼吸症狀的心臟性與非心臟性原因,並可用於檢測臨床症狀出現前的心肌病變。越來越多的研究顯示,心臟生物標誌物檢測有助於評估患有心臟疾病動物的發病與死亡風險。在臨床實務中,心臟生物標誌物檢測的有效使用依賴於正確的患者篩選、準確解讀檢測結果,並將其與現有的診斷方法相結合。

關鍵字: BNP;心臟生物標誌物;心臟疾病;利鈉肽;鈣蛋白