健康日本人的內臟脂肪與C-反應蛋白關聯研究揭示動脈硬化風險

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研究發現，在日本健康成人中，C-反應蛋白（CRP）水平與內臟脂肪積累有顯著關聯，尤其是腰圍和腰臀比這些內臟肥胖指標比其他肥胖指標更與CRP關聯緊密。這些結果支持內臟脂肪在動脈硬化的炎症過程中可能扮演的角色，並促使進一步探索內臟脂肪如何引起CRP上升的機制。

Y Saijo 1, N Kiyota, Y Kawasaki, Y Miyazaki, J Kashimura, M Fukuda, R Kishi
Affiliations expand
PMID: 15171748 DOI: 10.1111/j.1462-8902.2003.0342.x

https://pubmed.ncbi.nlm.nih.gov/15171748/

Abstract

Recent studies have suggested that the elevated C-reactive protein (CRP) levels are associated with body fat, especially visceral adipose tissue, but most of them were investigated in Westerners who had higher body mass index (BMI) than Asians. To investigate the association between CRP concentrations, parameters of visceral obesity, the insulin resistance syndrome and carotid atherosclerosis in healthy Japanese who had a lower BMI than Westerners.

We explored the relationships between fatness and visceral obesity parameters [by anthropometry, bioelectrical impedance analysis and abdominal computed tomography (CT)] and CRP (high sensitivity) and examined their associations with components of insulin resistance syndrome, interleukin-6 (IL-6), tissue necrosis factor-alpha (TNF-alpha) and intima-media thickness (IMT) of common carotid arteries (CCAs) by ultrasonograms in 116 healthy Japanese subjects.

In crude regression analyses, CRP was significantly associated with measures of obesity. After adjustment for age, gender and smoking, the association with CRP was stronger for parameters of visceral obesity (waist circumference, waist-to-hip ratio and visceral adipose tissue accumulation) than for other parameters of obesity. IL-6 and TNF-alpha were not associated with CRP. Blood pressure (BP), metabolic variables and CCA-IMT were also significantly associated with CRP. But, after being adjusted for age, gender, smoking and BMI, BP and high-density lipoprotein cholesterol (HDLc) were significantly associated.

CRP level is associated with visceral adipose tissue and is significantly associated with the components of insulin resistance syndrome in healthy Japanese subjects. These data support a possible role of visceral adipose tissue in inflammation component of atherosclerosis, and further studies are needed to study the mechanism of CRP elevation caused by visceral adipose tissue.

摘要

最近的研究表明，C-反應蛋白（CRP）水平的升高與體脂肪，尤其是內臟脂肪相關，但大多數研究對象是體質指數（BMI）高於亞洲人的西方人。本研究旨在調查健康日本人（其BMI低於西方人）中CRP濃度、內臟肥胖參數、胰島素抗性綜合症和頸動脈粥樣硬化的關聯。

我們探索了116位健康日本受試者的脂肪和內臟肥胖參數（通過人體測量、生物電阻分析和腹部電腦斷層掃描[CT]）與高靈敏度CRP的關系，並檢查了它們與胰島素抗性綜合症組成部分、白介素-6（IL-6）、組織壞死因子-α（TNF-α）和共同頸動脈（CCA）內中膜厚度（IMT）之間的相關性。

在原始回歸分析中，CRP與肥胖測量指標顯著相關。經過年齡、性別和吸煙習慣調整後，CRP與內臟肥胖參數（腰圍、腰臀比和內臟脂肪組織堆積）的關聯更為強烈。IL-6和TNF-α與CRP無關。血壓（BP）、代謝變量和CCA-IMT也與CRP顯著相關。但是，在調整年齡、性別、吸煙習慣和BMI後，BP和高密度脂蛋白膽固醇（HDLc）與CRP顯著相關。

CRP水平與內臟脂肪組織相關，並與健康日本人的胰島素抗性綜合症組件顯著相關。這些數據支持內臟脂肪組織在動脈粥樣硬化炎症成分中可能扮演的角色，需要進一步研究內臟脂肪組織導致CRP升高的機制。