Roche cobas b101 CRP Testing

Point-of-care CRP testing with cobas® b 101

Guide for appropriate antibiotic use by rapid clinical evaluation of infection, inflammation and tissue injury

Roche’s cobas b 101 CRP test can be used with the corresponding cobas b 101 device to help diagnose and evaluate inflammatory processes and respiratory infections. The test delivers reliable CRP (c-reactive proteins) values over a wide measuring range (3 – 400 mg/L). The rapid and accurate results make the test ideal for using it in offices, clinics, and laboratories.

Please note: For healthcare professionals only. The test may only be performed and evaluated by a physician or a person authorized by a physician. Laypersons may use and evaluate the test incorrectly.

Importance of point-of-care (POC) CRP testing

	Diagnostic uncertainty leads to inappropriate antibiotic prescribing.1 Excessive and inappropriate antibiotic use contributes to antibiotic resistance, which is a growing threat to global public health.2
	CRP testing supports differentiation between bacterial and viral infections and guides appropriate antibiotic use in primary care by decreasing diagnostic uncertainty. CRP testing reduces antibiotic prescription rate without compromising patient recovery.3-5

• • For determining blood’s CRP contentHelps evaluate inflammatory processes and associated diseases
  • Supportive diagnostics of respiratory infections and antibiotic use
  • High working safety thanks to a direct sample application on the disc
  • For use with Roche’s cobas b 101 device
  • Specimen material: capillary and venous whole blood
  • Specimen volume: 12 μL
  • Measuring time: ≤ 4 minutes
  • Specimen stability: 2 minutes
  • Measuring range: 3 – 400 mg/L

cobas® C-reactive protein (CRP) test

cobas® CRP test is used in POC or clinical laboratory settings, to determine C-reactive protein, a biomarker for infection, inflammatory disorders and tissue injury6

	12 μL Fresh capillary whole blood or serum7 (EDTA K2/K3 or lithium heparin anticoagulated whole blood or plasma)
	Direct application from single finger prick7

	Shelf life 16 months at room temperature7

Key benefits of cobas® b 101

• Easy and safe handling of samples and test discs
• Comprehensive connectivity and data management
• User-friendly, robust and service-free
• Professional laboratory-standard analytical performance in the POC setting8

References

1. Klein, E. et al. (2018). Global increase and geographic convergence in antibiotic consumption between 2000
and 2015. Proc Natl Acad Sci U S A 115, E3463–E3470.
2. O’Brien, K. et al. (2019). C-reactive protein point-of-care testing (CRP POCT) to guide antibiotic prescribing
in primary care settings for acute respiratory tract infections (RTIs). Rapid assessment on other health
technologies using the HTA Core Model for Rapid Relative Effectiveness Assessment. EUnetHTA Project ID: OTCA012.
3. Abenhus, R. et al (2014). Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute
respiratory infections in primary care. Cochrane Database Syst Rev 2014:CD010130
4. Anthierens, S. et al. (2015). Clinicians’ views and experiences of interventions to enhance the quality of antibiotic
prescribing for acute respiratory tract infections. J Gen Intern Med 30, 408–416.
5. Cooke, J , et al. (2015). Narrative review of primary care point-of-car testing (POCT) and antibacterial
use in respiratory tract infection (RTI). BMJ Open Respir Res 2, e000086.
6. Cals, J.W.L. et al (2011). J Eval Clin Pract 17:1059–1069
7. Roche Diagnostics International Ltd. cobas CRP Test Method Sheet Version 2.0
8. Scharnhorst, V. et al. (2019). A multicenter evaluation of a point of care CRP test. Clinical Biochemistry
71, 38–45