醣時
4 D-Dimer with the cobas h 232 POC system
For exclusion of suspected Pulmonary Embolism (PE) or Deep Vein Th rombosis (DVT)8
Guideline recommended
European Society of Cardiology (ESC) guidelines on the diagnosis and management of acute PE
recommend D-Dimer testing on patients with low/ moderate clinical probability of PE.
The proposed diagnostic algorithm includes a D-dimer test used in conjunction with the clinical probability score.8
Rapid reliable exclusion test
- When used in conjunction with a low to moderate pre-test probability score, a negative D-Dimer test has shown to have 100 % negative predictive value14
- A positive D-Dimer test does not confi rm the PE or DVT diagnosis. Further imaging diagnostic procedure is then required
Save time and costs
- Rule out PE/DVT in patients with low to moderate probability in less than 10 minutes3
- Avoid hospital admission for patients with negative D-Dimer results and low to moderate pre-test probability
- Reduce unnecessary imaging15
Available tests
The cobas h 232 POC system allows rapid and easy determination of Troponin T, NT-proBNP, D-Dimer, CK-MB and Myoglobin in different settings, like ambulances, general practitioner offices and emergency rooms.
Test |
Measuring range |
Time to result |
Clinical utility |
Troponin |
40 – 2,000 ng/L | 12 min | Early aid in diagnosis of acute myocardial infarction and identification of patients with an elevated mortality risk4 |
NT-proBNP |
60 – 9,000 pg/mL | 12 min | Aid in diagnosis of patients with suspected heart failure, in monitoring of patients with compensated left ventricular dysfunction and in the risk stratification of patients with acute coronary syndromes5 |
CK-MB |
1.0 – 40 ng/mL | 12 min | Aid in diagnosis of patients with suspected acute myocardial infarction (AMI, heart attack), assessment of the size of the infarction and detection of re-infarction1 |
D-Dimer |
0.1 – 4.0 µg/mL | 8 min | Aid in exclusion of deep venous thrombosis and pulmonary embolism2 |
Myoglobin |
30 – 700 ng/mL | 8 min | Aid in diagnosis of patients with suspected myocardial infarction, reperfusion control3 |
References
1 Bertsch, T. et al. (2010). Clin Lab. 56(1-2), 37-49.
2 Roche (2016). cobas h 232 POC system Operator’s Manual, Version 6.0.
3 Roche CARDIAC D-Dimer-Method Sheet-package insert.
4 Roche CARDIAC proBNP-Method Sheet-package insert.
5 Roche CARDIAC POC Troponin T-Method Sheet-package insert.
6 Roche CARDIAC CK-MB-Method Sheet-package insert.
7 Roche CARDIAC M-Method Sheet-package insert.
8 Konstantinides, S. et al. (2014). Eur Heart J 35, 3033-3080.
9 Ponikowski, P. et al. (2016). Eur J Heart Fail 18(8), 891-975.
10 Roffi , M. et al. (2015). Eur Heart J 37(3), 267-315.
11 Stengaard, C. et al. (2013). American J Cardiol 112(9), 1361-1366.
12 Achar, S.A. et al. (2005). Am Fam Physician 72(1), 119-126.
13 Jungbauer, C. et al. (2017). Clin Lab 63(4), 633-645.
14 De Bastos, M.M. et al. (2008). Blood Coagul Fibrinolysis 19(1),
48–54.
15 Wells, P.S. et al. (2003). N Engl J Med 349(13), 416-420.
16 Berliner, D. et al. (2016). Dtsch Arztebl Int 113(49), 834-845.
17 Taylor, C.J. et al. (2017). Br J Gen Pract. 67(655), e94-e102.
18 Taylor, C.J. et al. (2017). Effi cacy and Mechanism Evaluation, No. 4.3. National Institute for Health. Research. ISSN 2050-4365. [Accessed September 2018].
19 British Heart Foundation and the All-Party Parliamentary Group on Heart Disease (2016). Focus on Heart Failure. Report accessible on https://www.bhf.org.uk/get-involved/campaigning/inquiry-
intoliving-with-heart-failure [Accessed September 2018].
20 Januzzi, J.L. et al. (2006). Eur Heart J 27(3), 330-337.
21 Januzzi, J.L. et al. (2018). J Am Coll Cardiol 71(11), 1191-1200.
22 Masson, S. et al. (2008). J Am Coll Cardiol 52, 997-1000.
23 DeBeradinis, B., Januzzi, J.L. (2012). Curr Opin Cardiol 27(6):
661-668.
24 Chiong, J. (2010). Heart Fail Rev. 15(4), 275-291.
25 Weiner, R. (2012). Eur J Heart Fail 15(3), 342-351.
26 Januzzi (2012). Arch Cardiovasc Dis. 105(1), 40-50.
27 Januzzi, J.L. et al. (2016). Clin Chem 62(5), 663-665.
28 Stengaard, C. et al. (2016). European Heart Journal: Acute Cardiovascular Care, 1-10.
