糖化血紅蛋白(HbA1c)檢測方法及其干擾因素的專家審查

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本審查著重於不同的糖化血紅蛋白(HbA1c)檢測方法,特別是血紅蛋白變異對檢測結果的干擾。每種HbA1c檢測方法都有其優點和挑戰,例如對干擾的敏感性。血紅蛋白變異及異常的紅血球周轉不僅會干擾HbA1c的分析測量,還可能影響其臨床解釋。因此,熟悉這些方法的優缺點對於基於HbA1c結果制定治療管理和目標至關重要,尤其是在高血紅蛋白變異率的人群中。

病理學會診:HbA(1c)檢測方法及干擾因素

Pathology consultation on HbA(1c) methods and interferences

Rhea JM, Molinaro R. Pathology consultation on HbA(1c) methods and interferences. Am J Clin Pathol. 2014 Jan;141(1):5-16. doi: 10.1309/AJCPQ23GTTMLAEVL. PMID: 24343732.

https://pubmed.ncbi.nlm.nih.gov/24343732/

Abstract

Objectives

To review the various hemoglobin (Hb) A1c methods, with a focus on interferences resulting from Hb variants.

Methods

HbA1c is a marker used for the diagnosis and management of diabetes. Each available HbA1c method has advantages and challenges, such as its susceptibility to interferences.

Results

The presence of Hb variants and/or abnormalities in RBC turnover cannot only interfere analytically with HbA1c measurements but also may affect the clinical interpretation of HbA1c values.

Conclusions

Familiarity with the advantages and challenges of the various methods used for HbA1c testing is essential when establishing therapeutic management and goals based on HbA1c results, especially in populations with a high prevalence of Hb variants.

Keywords

Blood glucose concentrations; Diabetes; HbA1c interferences; HbA1c interpretation; HbA1c methods.

摘要

目標

回顧各種血紅蛋白(Hb)A1c測定方法,重點關注來自Hb變體的干擾。

方法

HbA1c是用於診斷和管理糖尿病的標誌。每種可用的HbA1c方法都有其優點和挑戰,例如其對干擾的敏感性。

結果

Hb變體的存在和/或紅血球(RBC)周轉異常不僅可能在分析上干擾HbA1c測量,還可能影響HbA1c值的臨床解釋。

結論

熟悉用於HbA1c檢測的各種方法的優點和挑戰,在根據HbA1c結果建立治療管理和目標時至關重要,特別是在Hb變體高發人群中。

關鍵詞

血糖濃度;糖尿病;HbA1c干擾;HbA1c解釋;HbA1c方法。