突破性研究揭示:遠紅外線加速大鼠皮膚傷口癒合

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最新研究發現,遠紅外線(FIR)對皮膚傷口的癒合過程有顯著促進作用。研究團隊使用大鼠模型證明,FIR能加速全層皮膚傷口的癒合,而這一效果與傳統認為的溫熱作用無關。FIR促進膠原再生及增加表達變態生長因子-β1(TGF-β1)的成纖維細胞,為未來醫療治療提供了新的研究方向。

遠紅外線對大鼠全層皮膚傷口癒合的促進效果

Promotive effects of far-infrared ray on full-thickness skin wound healing in rats

Hideyoshi Toyokawa 1, Yoichi Matsui, Junya Uhara, Hideto Tsuchiya, Shigeru Teshima, Hideki Nakanishi, A-Hon Kwon, Yoshihiko Azuma, Tetsuo Nagaoka, Takafumi Ogawa, Yasuo Kamiyama
Affiliations expand
PMID: 12773705 DOI: 10.1177/153537020322800612

https://pubmed.ncbi.nlm.nih.gov/12773705/

摘要

遠紅外線(FIR)對整個生物體的生物效應尚不完全了解。我們的研究目的是研究不僅FIR輻射的增溫效應,還有FIR對傷口癒合的生物效應。為了評估FIR對皮膚傷口部位的影響,我們使用大鼠模型比較了有和沒有FIR的全層皮膚傷口癒合速度。我們測量了皮膚傷口面積、皮膚血流和皮膚溫度,在FIR輻射之前和期間,並進行了組織學檢查。與沒有FIR的組相比,FIR組的傷口癒合顯著更快。皮膚血流和皮膚溫度在FIR輻射之前或期間沒有顯著改變。組織學發現顯示,FIR組的傷口中膠原再生更多,並且滲入了表達變態生長因子-β1(TGF-β1)的成纖維細胞。可能的機制是,FIR對傷口癒合的促進效應獨立於皮膚血流和皮膚溫度,可以通過刺激TGF-β1的分泌或成纖維細胞的激活來考慮。

Abstract

The biological effects of far-infrared ray (FIR) on whole organisms remain poorly understood. The aim of our study was to investigate not only the hyperthermic effect of the FIR irradiation, but also the biological effects of FIR on wound healing. To evaluate the effect of FIR on a skin wound site, the speed of full-thickness skin wound healing was compared among groups with and without FIR using a rat model. We measured the skin wound area, skin blood flow, and skin temperature before and during FIR irradiation, and we performed histological inspection. Wound healing was significantly more rapid with than without FIR. Skin blood flow and skin temperature did not change significantly before or during FIR irradiation. Histological findings revealed greater collagen regeneration and infiltration of fibroblasts that expressed transforming growth factor-beta1 (TGF-beta1) in wounds in the FIR group than in the group without FIR. Stimulation of the secretion of TGF-beta1 or the activation of fibroblasts may be considered as a possible mechanisms for the promotive effect of FIR on wound healing independent of skin blood flow and skin temperature.